Buy Bumetanide powder (28395-03-1) hplc≥98% – β-Agonist Wisepowder

Buy Bumetanide powder (28395-03-1) hplc≥98% – β-Agonist Wisepowder https://www.wisepowder.com/product-details/28395-03-1/ Chemical Base Information Name Bumetanide powder CAS 28395-03-1 Purity 98% Chemical name 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid Synonyms Bumetanide, Trade names: Bumex or Burinex; PF 1593, PF-1593, PF1593 Molecular Formula C17H20N2O5S Molecular Weight 364.416…

Buy Bumetanide powder (28395-03-1) hplc≥98% - β-Agonist Wisepowder

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Buy Bumetanide powder (28395-03-1) hplc≥98% – β-Agonist Wisepowder

https://www.wisepowder.com/product-details/28395-03-1/

Chemical Base Information
Name Bumetanide powder
CAS 28395-03-1
Purity 98%
Chemical name 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Synonyms Bumetanide, Trade names: Bumex or Burinex; PF 1593, PF-1593, PF1593
Molecular Formula C17H20N2O5S
Molecular Weight 364.416 g/mol
Melting Point 230-232°C.
InChI Key MAEIEVLCKWDQJH-UHFFFAOYSA-N
Form Solid
Appearance
Half Life 30 to 60 minutes
Solubility Soluble in DMSO, not in water
Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Application Bumetanide is a Loop Diuretic. The physiologic effect of bumetanide is by means of Increased Diuresis at Loop of Henle.
Testing Document Available

03 Bumetanide powder (28395-03-1) General Description
Bumetanide powder is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency.

Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.

04 Bumetanide powder (28395-03-1) History
Bumetanide powder, sold under the trade name Bumex among others, is a medication used to treat swelling and high blood pressure. This include swelling as a result of heart failure, liver failure, or kidney problems. It may work for swelling when other medications have not. For high blood pressure it is not a preferred treatment. It is taken by mouth, or by injection into a vein or muscle. Effects generally begin within an hour and lasts for about six hours.

Bumetanide was patented in 1968 and came into medical use in 1972. It is available as a generic medication. In 2016 it was the 266th most prescribed medication in the United States with more than a million prescriptions.

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