Molecular Formula C20H33N3O4
Molecular Weight 379.501 g/mol
Melting Point 198 to 200°C
InChI Key JOATXPAWOHTVSZ-UHFFFAOYSA-N
Half Life approximately 5-6 hours
Solubility soluble in water
Storage Condition 0 – 4 C for short term (days to weeks), or -20 C for long term (months)
Application Celiprolol is currently approved for the treatment of management of mild to moderate hypertension and effort-induced angina pectoris.
Testing Document Available
03 Celiprolol (56980-93-9) General Description
Celiprolol is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist.
Celiprolol is believed to provide clinical benefit for people with vascular Ehlers–Danlos syndrome by promoting normal collagen synthesis in the blood vessels, and by shifting the pressure load away from the vessels most prone to dissection and rupture. In 2019, a new drug application (NDA) for celiprolol was denied by the Food an the U.S. Food and Drug Administration (FDA), instead calling for an “adequate and well-controlled” trial to determine whether celiprolol reduced the risk of clinical events in patients with vEDS.
It was patented in 1973 and approved for medical use in 1982.
04 Celiprolol (56980-93-9) History
Celiprolol side effects includes:
Feeling dizzy, sleepy, tired or light-headed, Headache, Feeling sick (nausea) or being sick (vomiting), stomach upset